Berubicin Hydrochloride

Preferred Label : Berubicin Hydrochloride;

NCIt synonyms : (8S,10S)-10-((3-amino-4-O-benzyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)- 6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride;

NCIt related terms : RTA 744; topoisomerase II inhibitor RTA 744;

NCIt definition : The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB).;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of adult brain tumors. RTA 744 crosses the blood-brain barrier and blocks an enzyme needed for cancer growth. It is a type of topoisomerase inhibitor.;

UNII : 7BA3X03948;

InChIKey : GPMIHHFZKBVWAZ-LMMKTYIZSA-N;

CAS number : 293736-67-1;

Molecule name : WP744; RTA 744;

Chemical formula : C34H35NO11.HCl;

NCI Metathesaurus CUI : CL364772;

Codes from synonyms : CDR0000535498; CDR0000514445;

Details

Origin ID

C61568;

UMLS CUI

C2713012;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
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- Berubicin [NCIt concept]
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- Topoisomerase II [NCIt concept]
is_salt_form_of
- Berubicin [NCIt concept]

Keyword's position in hierarchy(ies) :

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