Preferred Label : Berubicin Hydrochloride;
NCIt synonyms : (8S,10S)-10-((3-amino-4-O-benzyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)- 6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
Hydrochloride;
NCIt related terms : RTA 744; topoisomerase II inhibitor RTA 744;
NCIt definition : The hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic
activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity,
resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier
(BBB).;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of adult brain tumors. RTA 744
crosses the blood-brain barrier and blocks an enzyme needed for cancer growth. It
is a type of topoisomerase inhibitor.;
UNII : 7BA3X03948;
InChIKey : GPMIHHFZKBVWAZ-LMMKTYIZSA-N;
CAS number : 293736-67-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 293736-67-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : WP744; RTA 744;
Chemical formula : C34H35NO11.HCl;
NCI Metathesaurus CUI : CL364772;
Codes from synonyms : CDR0000535498; CDR0000514445;
Origin ID : C61568;
UMLS CUI : C2713012;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
