Preferred Label : Berubicin;
NCIt synonyms : (8S,10S)-10-((3-Amino-4-O-Benzyl-2,3,6-Trideoxy-A-L-Lyxo-Hexopyranosyl)Oxy)-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione; 5,12-Naphthacenedione, 10-((3-Amino-2,3,6-Trideoxy-4-O-(Phenylmethyl)-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-,
(8S,10S)-;
NCIt definition : A 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential
antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase
II activity, resulting in the inhibition of DNA replication and repair, as well as
RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses
the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux.;
UNII : 6QPN83HK2M;
InChIKey : FIGNGSHKNAHTSH-JJMFXPFOSA-N;
CAS number : 677017-23-1;
Chemical formula : C34H35NO11;
Origin ID : C83552;
UMLS CUI : C2827086;
Semantic type(s)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
