NCIt definition : A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds
to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA
repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells
in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat testicular and small cell lung cancers. It is also
being studied in the treatment of several other types of cancer. Etopophos blocks
certain enzymes needed for cell division and DNA repair, and it may kill cancer cells.
It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.;
UNII : 528XYJ8L1N;
InChIKey : LIQODXNTTZAGID-OCBXBXKTSA-N;
CAS number : 117091-64-2;
Drug name : Etopophos;
Chemical formula : C29H33O16P;
Codes from synonyms : CDR0000350228; CDR0000520360;
Semantic type(s)