Preferred Label : Etoposide;
NCIt synonyms : Demethyl Epipodophyllotoxin Ethylidine Glucoside; EPEG; 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside]; Vepesid;
NCIt related terms : VP 16-213; Toposar; VP-16;
NCIt definition : A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake
root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide
binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules,
resulting in the accumulation of single- or double-strand DNA breaks, the inhibition
of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily
in the G2 and S phases of the cell cycle. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat testicular and small cell lung cancers. It is also
being studied in the treatment of several other types of cancer. Vepesid blocks certain
enzymes needed for cell division and DNA repair, and it may kill cancer cells. It
is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.;
UNII : 6PLQ3CP4P3;
InChIKey : VJJPUSNTGOMMGY-MRVIYFEKSA-N;
CAS number : 33419-42-0;
Drug name : Lastet;
Molecule name : VP-16; VP-16-213; VP 16; VP 16213;
Chemical formula : C29H32O13;
NSC code : 141540;
ChEBI ID : CHEBI:4911;
Codes from synonyms : 30262; CDR0000045189; NSC0141540; CDR0000601302; CDR0000601304; 201;
Origin ID : C491;
UMLS CUI : C0015133;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://www.has-sante.fr/jcms/p_3535833/fr/etoposide-hikma-etoposide-oncologie
2024
false
false
false
France
drugs, generic
evaluation of the transparency committee
etoposide
etoposide
Etoposide
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