Preferred Label : Doxorubicin;
NCIt synonyms : Hydroxyl Daunorubicin; Hydroxyldaunorubicin; (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione; 14-Hydroxydaunomycin; (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; Adriablastin; Hydroxydaunomycin;
NCIt definition : An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from
the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of
daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby
preventing DNA replication and ultimately inhibiting protein synthesis. Additionally,
doxorubicin inhibits topoisomerase II which results in an increased and stabilized
cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents
the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also
forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation
of cell membrane lipids; the formation of oxygen free radicals also contributes to
the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular
effects.;
Alternative definition : NCI-GLOSS: A drug that is used to treat many types of cancer and is being studied
in the treatment of other types of cancer. Doxorubicin comes from the bacterium Streptomyces
peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline
antitumor antibiotic.;
UNII : 80168379AG;
InChIKey : AOJJSUZBOXZQNB-TZSSRYMLSA-N;
CAS number : 23214-92-8;
Chemical formula : C27H29NO11;
ChEBI ID : CHEBI:28748;
Codes from synonyms : NSC0123127; CDR0000045140; 170;
Origin ID : C456;
UMLS CUI : C0013089;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
