Preferred Label : Doxorubicin Hydrochloride;
NCIt synonyms : 3-Hydroxyacetyldaunorubicin Hydrochloride; ADM; Adriamycine; Chloridrato de Doxorrubicina; 14-Hydroxydaunorubicin Hydrochloride; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride,
(8S-cis)-(9CI); Adriamycin PFS; L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl
3-amino-2,3,6-trideoxy-alpha-, hydrochloride; Doxorubicin HCl;
NCIt related terms : hydroxydaunorubicin; Doxorubicin.HCl; ADRIAMYCIN, HYDROCHLORIDE; FI 106; Adriblastina; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,
9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
(9CI); Adriamycin RDF; Adriacin; Adriamycin hydrochloride; Rubex; DOX;
NCIt definition : The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic
activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius,
is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base
pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting
protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results
in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication
and subsequently prevents the ligation of the nucleotide strand after double-strand
breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary
to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals
also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac
and cutaneous vascular effects.;
Alternative definition : NCI-GLOSS: A drug that is used to treat many types of cancer and is being studied
in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium
Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of
anthracycline antitumor antibiotic.;
UNII : 82F2G7BL4E;
InChIKey : MWWSFMDVAYGXBV-RUELKSSGSA-N;
CAS number : 25316-40-9;
Drug name : Adriamycin; Adriacin; Doxolem; Farmiblastina; Adriblastina; Adrimedac; Doxorubin; Rubex; DOXO-CELL; Adriblastine;
Molecule name : FI-106; FI 106;
Chemical formula : C27H29NO11.HCl;
NSC code : 123127;
Codes from synonyms : CDR0000560140; CDR0000560141; CDR0000560142; CDR0000560143; NSC0123127; CDR0000636400; 00195;
Origin ID : C1326;
UMLS CUI : C0546861;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
