Preferred Label : Liposome-Encapsulated Doxorubicin Citrate;
NCIt related terms : DOXORUBICIN CITRATE; Non-pegylated liposomal doxorubicin;
NCIt definition : A formulation of the citrate salt of the antineoplastic anthracycline antibiotic doxorubicin,
encapsulated within liposomes, with antitumor activity. Doxorubicin intercalates into
DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and RNA
synthesis. This agent also interacts with cell membrane lipids causing lipid peroxidation.
Liposomal delivery of doxorubicin improves drug penetration into tumors and decreases
drug clearance, thereby increasing the duration of therapeutic drug effects while
lowering the toxicity profile.;
Alternative definition : NCI-GLOSS: A form of the anticancer drug doxorubicin citrate that is contained inside
very tiny, fat-like particles. It is being studied in the treatment of breast cancer
that has spread and in the treatment of other types of cancer. Doxorubicin citrate
damages DNA and may kill cancer cells. Liposomal-encapsulated doxorubicin citrate
may have fewer side effects and may work better than doxorubicin citrate.;
UNII : AJQ2ZNG2WL;
CAS number : 111266-55-8;
Drug name : Myocet;
Codes from synonyms : CDR0000648674; 359;
Origin ID : C61317;
UMLS CUI : C1831805;
Semantic type(s)
- concept_is_in_subset
- has_target
