Amonafide L-Malate

Preferred Label : Amonafide L-Malate;

NCIt synonyms : Butanedioic Acid, 2-hydroxy-, (2S)-, compd. with 5-amino-2-(2-(dimethylamino)ethyl)-1h-benz[de]isoquinoline-1,3(2h)-dione (1:1); 5-amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione (2S)-2-ydroxybutanedioate;

NCIt definition : The malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.;

UNII : LI06Q37TEG;

InChIKey : JNZBHHQBPHSOMU-WNQIDUERSA-N;

CAS number : 618863-54-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 618863-54-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Xanafide;

Molecule name : AS1413; XAN-02;

Chemical formula : C16H17N3O2.C4H6O5;

Details

Origin ID

C61306;

UMLS CUI

C1831822;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Amonafide [NCIt concept]
has_target
- Topoisomerase II [NCIt concept]
is_salt_form_of
- Amonafide [NCIt concept]

Keyword's position in hierarchy(ies) :

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