" /> Amonafide L-Malate - CISMeF





Preferred Label : Amonafide L-Malate;

NCIt synonyms : Butanedioic Acid, 2-hydroxy-, (2S)-, compd. with 5-amino-2-(2-(dimethylamino)ethyl)-1h-benz[de]isoquinoline-1,3(2h)-dione (1:1); 5-amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione (2S)-2-ydroxybutanedioate;

NCIt definition : The malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-strand breaks (DSB) and inhibition of DNA replication and RNA synthesis.;

UNII : LI06Q37TEG;

InChIKey : JNZBHHQBPHSOMU-WNQIDUERSA-N;

CAS number : 618863-54-0;

Drug name : Xanafide;

Molecule name : AS1413; XAN-02;

Chemical formula : C16H17N3O2.C4H6O5;

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08/05/2025


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