Preferred Label : Annamycin Liposomal;
NCIt definition : A liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin
with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase
II, resulting in the inhibition of DNA replication and repair and RNA and protein
synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including
P-glycoprotein (P-gp). Liposomal annamycin is less toxic and shows improved antitumor
activity compared to annamycin.;
NSC code : 700363;
Origin ID : C25838;
UMLS CUI : C0935796;
Semantic type(s)
- concept_is_in_subset
- has_target
