Preferred Label : Banoxantrone;
NCIt synonyms : 9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-, N,N'-dioxide;
NCIt definition : A bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under
hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and
activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to
the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks
DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication
and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic
and hypoxic regions of tumors can be targeted.;
UNII : W5H7E45YT3;
InChIKey : YZBAXVICWUUHGG-UHFFFAOYSA-N;
CAS number : 136470-65-0;
Molecule name : Aq4N; AQ 4N;
Chemical formula : C22H28N4O6;
Origin ID : C79528;
UMLS CUI : C0299316;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- AQ4N [MeSH Supplementary Concept]
- Validated automatic mappings to BTNT
- AQ4N [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
