Preferred Label : PVA Microporous Hydrospheres/Doxorubicin Hydrochloride;
NCIt synonyms : HepaSphere Microspheres/Doxorubicin Hydrochloride; QuadraSphere Microspheres/Doxorubicin Hydrochloride; PVA Microporous Hydrospheres Doxorubicin Hydrochloride;
NCIt definition : An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded
with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded
microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature.
Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase
II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition
and apoptosis. When used in tumor vasculature embolization, this preparation may provide
more tumor-specific treatment with doxorubicin compared to the systemic administration
of doxorubicin, thereby reducing the systemic toxicity of doxorubicin.;
NCI Metathesaurus CUI : CL376223;
Origin ID : C71149;
UMLS CUI : C2347439;
Semantic type(s)
- concept_is_in_subset
- has_target
