Preferred Label : Lyso-Thermosensitive Liposome Doxorubicin;
NCIt synonyms : Temperature Sensitive Liposome Encapsulated Doxorubicin; Heat-Activated Liposomal Doxorubicin Hydrochloride;
NCIt definition : A temperature-sensitive liposomal formulation of the anthracycline antibiotic doxorubicin
with potential antineoplastic activity. Upon intravenous administration, circulating
thermosensitive liposomes are activated locally by increasing the tumor temperature
to 40-41 degrees Celsius using an external heat source. The elevated temperature causes
compositional changes in the liposomes, creating openings that allow for the release
of encapsulated doxorubicin. Compared to non-thermosensitive liposomes, lyso-thermosensitive
liposomes deliver higher concentrations of a cytotoxic agent to a heat-treated tumor
site while sparing normal tissues unexposed to heat treatment.;
Drug name : ThermoDox;
Origin ID : C61571;
UMLS CUI : C1831903;
Semantic type(s)
- concept_is_in_subset
- has_target
