Lucanthone - CISMeF

Preferred Label : Lucanthone;

NCIt definition : An orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in un-repaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy.;

UNII : FC6D57000M;

InChIKey : FBQPGGIHOFZRGH-UHFFFAOYSA-N;

CAS number : 479-50-5;

Chemical formula : C20H24N2OS;

ChEBI ID : CHEBI:51052;

Details

Origin ID

C83925;

UMLS CUI

C0024071;

Automatic exact mappings (from CISMeF team)
- Lucanthone [ICHI extension code]
Currated CISMeF NLP mapping
- Lucanthone [ICD-11 Extension code]
- Lucanthone (substance) [SNOMED CT concept]
- lucanthone [Substance BNPC]
- lucanthone [MeSH Descriptor]
- lucanthone [MeSH concept]
- lucanthone [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lucanthone [ICD-11 Extension code]
- Lucanthone (substance) [SNOMED CT concept]
- lucanthone [Substance BNPC]
- lucanthone [MeSH concept]
- lucanthone [MeSH Descriptor]
- lucanthone [SNOMED Notion]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Lucanthone Hydrochloride [NCIt concept]
has_target
- DNA Topoisomerase 1 [NCIt concept]
- DNA-(Apurinic or Apyrimidinic Site) Lyase [NCIt concept]
- Topoisomerase II [NCIt concept]
is_free_acid_or_base_form_of
- Lucanthone Hydrochloride [NCIt concept]

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