Preferred Label : Teniposide;
NCIt synonyms : Thenylidene Lignan; 4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside; PTG; 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside); EPT; [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;
NCIt related terms : VM-26; VM 26; Vumon; Vehem;
NCIt definition : A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide
forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent
single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of
DNA strand religation, and cytotoxicity. This agent acts in the late S or early G
phase of the cell cycle. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that is a podophyllotoxin derivative and belongs to
the family of drugs called mitotic inhibitors.;
UNII : 957E6438QA;
InChIKey : NRUKOCRGYNPUPR-QBPJDGROSA-N;
CAS number : 29767-20-2;
Drug name : Vumon; Vehem;
Molecule name : VM-26;
Chemical formula : C32H32O13S;
NSC code : 122819;
Codes from synonyms : 30235; CDR0000046766; NSC0122819; 486;
Origin ID : C857;
UMLS CUI : C0039512;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
