teniposide - CISMeF

Preferred Label : teniposide;

MeSH definition : A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.;

MeSH synonym : demethyl epipodophyllotoxin thenylidine glucoside;

CISMeF synonym : Bristol-Myers brand of teniposide; bristol myers brand of teniposide; Bristol-Myers squibb brand of teniposide; bristol myers squibb brand of teniposide;

MeSH hyponym : vumon; VM-26; NSC-122819; VM 26; VM26; NSC 122819; NSC122819;

Related MeSH term : teniposide, (5a alpha,9 alpha(S*))-Isomer;

MeSH CAS label : Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-((4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl)oxy)-, (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-;

MeSH Related Number : teniposide, (5a alpha,9 alpha(S*))-Isomer; 29767-20-2 (Teniposide); 53956-10-8 (cpd without chiral (R*/S*) notation); 89301-94-0 ((5a alpha,9 alpha(S*))-isomer);

Registry Number MeSH : 29767-20-2;

Related CAS MeSH : 89301-94-0 (Teniposide, (5a alpha,9 alpha(S*))-Isomer);

Wikipedia link : https://en.wikipedia.org/wiki/Teniposide;

Codes EINECS : 249-831-2;

Is substance : O;

UNII : 957E6438QA;

InChIKey : NRUKOCRGYNPUPR-QBPJDGROSA-N;

Details

Origin ID

D013713;

UMLS CUI

C0039512;

ATC code(s)
- teniposide [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Teniposide [ICHI extension code]
CISMeF manual mappings
- teniposide [Substance BNPC]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
- topoisomerase II inhibitors [MeSH Descriptor]
Record concept(s)
- NSC-122819 [MeSH concept]
- VM-26 [MeSH concept]
- teniposide [MeSH concept]
- teniposide, (5a alpha,9 alpha(S*))-Isomer [MeSH concept]
- vumon [MeSH concept]
Related MeSH Supplementary Concept(s)
- ALL-82 protocol [MeSH Supplementary Concept]
- ALL-85 protocol [MeSH Supplementary Concept]
- BBVDD protocol [MeSH Supplementary Concept]
- CAV-T protocol [MeSH Supplementary Concept]
- CHVP protocol [MeSH Supplementary Concept]
- CHVP regimen [MeSH Supplementary Concept]
- CHVmP-VB protocol [MeSH Supplementary Concept]
- CTVP protocol [MeSH Supplementary Concept]
- CVAP-B protocol [MeSH Supplementary Concept]
- CVP protocol 2 [MeSH Supplementary Concept]
- DHACT protocol [MeSH Supplementary Concept]
- LLA-IV-AR protocol [MeSH Supplementary Concept]
- LTPP protocol [MeSH Supplementary Concept]
- MATCOP regimen [MeSH Supplementary Concept]
- MBVP protocol [MeSH Supplementary Concept]
- MV26PD protocol [MeSH Supplementary Concept]
- MVLP protocol [MeSH Supplementary Concept]
- OPEC protocol 1 [MeSH Supplementary Concept]
- OPEC-D protocol [MeSH Supplementary Concept]
- TOTAL-XII protocol [MeSH Supplementary Concept]
- VAMA protocol [MeSH Supplementary Concept]
- VCD protocol [MeSH Supplementary Concept]
- VCE protocol [MeSH Supplementary Concept]
- VIM3 protocol [MeSH Supplementary Concept]
- VMM protocol [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing teniposide (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing teniposide (medicinal product) [SNOMED CT concept]
- Teniposide [ICD-11 Extension code]
- Teniposide [NCIt concept]
- Teniposide (substance) [SNOMED CT concept]
- teniposide [ATC Code]
- teniposide [Substance BNPC]
- teniposide [SNOMED Notion]
Validated automatic mappings to BTNT
- teniposide [ATC Code]

Keyword's position in hierarchy(ies) :

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