topoisomerase II inhibitors

Preferred Label : topoisomerase II inhibitors;

MeSH definition : Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.;

MeSH synonym : inhibitors, topoisomerase II; DNA type 2 topoisomerase inhibitors; topoisomerase 2 inhibitors; inhibitors, topoisomerase 2; DNA topoisomerase II inhibitors; DNA Topoisomerase II Inhibitor; Topoisomerase II Inhibitor; II Inhibitor, Topoisomerase; Inhibitor, Topoisomerase II;

MeSH hyponym : DNA gyrase inhibitors; Gyrase Inhibitors, DNA; Inhibitors, DNA Gyrase; DNA Gyrase Inhibitor; Gyrase Inhibitor, DNA; Inhibitor, DNA Gyrase;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D059005;

UMLS CUI

C1519554;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Topoisomerase-II Inhibitor [NCIt concept]
Indexing information
- 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)-3-fluoropiperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-7-carbonitrile [MeSH Supplementary Concept]
- 4,4'-(3H,3'H-5,5'-bibenzimidazole-2,2'-diyl)dianiline [MeSH Supplementary Concept]
- 4-((4'-benzylpiperdin-4-yl)amino)-4'-O-demethylepipodophyllotoxin [MeSH Supplementary Concept]
- 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)thiosemicarbazide [MeSH Supplementary Concept]
- 5,2',5'-trihydroxy-7,3',4'-trimethoxyflavone [MeSH Supplementary Concept]
- 6-(dodecylamino)-2-(3-(4-methylpiperazin-1-yl)propyl)-1H-benzo-(de)isoquinoline-1,3(2H)-dione [MeSH Supplementary Concept]
- DTA0100 [MeSH Supplementary Concept]
- anziaic acid [MeSH Supplementary Concept]
- dehydropachymic acid [MeSH Supplementary Concept]
- tricitinol B [MeSH Supplementary Concept]
MeSH Descriptor(s) used for indexing
- DNA gyrase [MeSH Descriptor]
- DNA topoisomerases, type II [MeSH Descriptor]
Record concept(s)
- DNA gyrase inhibitors [MeSH concept]
- topoisomerase II inhibitors [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- 1,2,3-O-acetyl-1,2,3-demethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine [MeSH Supplementary Concept]
- 1,3,4,5,6,7,8,10-octahydro-14-hydroxy-12-methoxy-11-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-6-thioxo-9,2,5-benzoxanthiaazacyclododecine-10-one [MeSH Supplementary Concept]
- 1,3,4,5,6,7,8,9,10,12-decahydro-16-hydroxy-14-methoxy-13-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-6-thioxo-11,2,5-benzoxathiaazacyclotetradecine-12-one [MeSH Supplementary Concept]
- 1-(3'-hydroxypropyl)-4,6,8-trimethylfuro(2,3-h)quinolin-2(1H)-one [MeSH Supplementary Concept]
- 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid [MeSH Supplementary Concept]
- 2,3-dihydroindolizino(7,6,5-kl)acridinium chloride [MeSH Supplementary Concept]
- 2-(2'-(dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de,h)isoquinoline-1,3-dione [MeSH Supplementary Concept]
- 2-(2-dimethylamino)-6-thia-2-azabenzo(def)chrysene-1,3-dione [MeSH Supplementary Concept]
- 2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-(2'',6''-di-O-(3'''-(4-fluorophenylpropanoyl)))galactosyl-4H-chromen-4-one [MeSH Supplementary Concept]
- 2-(4-methoxyphenyl)-5-((4-methylpiperazin-1-yl)-3H-imidazo(4,5-b)pyridin-2-yl)-3H-imidazo(4,5-b)pyridine [MeSH Supplementary Concept]
- 3'-deamino-3'-hydroxydoxorubicin [MeSH Supplementary Concept]
- 3-O-coumaroylbetulinic acid [MeSH Supplementary Concept]
- 3-amino-7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione [MeSH Supplementary Concept]
- 4'-O-demethyl-4-(4''-(benzimidazol-2''-yl)anilino)-4-desoxypodophyllotoxin [MeSH Supplementary Concept]
- 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione [MeSH Supplementary Concept]
- 4-benzoyl-1-(4-methyl-imidazol-5-yl)carbonylthiosemicarbazide [MeSH Supplementary Concept]
- 4-demethoxy-3'-deamino-3'-hydroxydoxorubicin [MeSH Supplementary Concept]
- 4-demethoxy-3'-deamino-4'-deoxy-4'-aminodaunorubicin [MeSH Supplementary Concept]
- 4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide [MeSH Supplementary Concept]
- 4-methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one [MeSH Supplementary Concept]
- 5,11-dimethyl-5H-indolo(2,3-b)quinoline [MeSH Supplementary Concept]
- 5,8-bis(2-aminoethylamino)-1-azaanthracene-9,10-dione [MeSH Supplementary Concept]
- 5-(2-(5-chloroindol-3-yl)vinyl)pyrazole [MeSH Supplementary Concept]
- 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one [MeSH Supplementary Concept]
- 7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione [MeSH Supplementary Concept]
- 7-(4-(4-tert-butylbenzyloxy)-1H-indazol-3-ylmethylsulfanyl)-4-methylcoumarin [MeSH Supplementary Concept]
- 8-azabatracylin [MeSH Supplementary Concept]
- 8-desaminobatracylin [MeSH Supplementary Concept]
- 9'-fluoro-10'-(4-methyl-1-piperazinyl)-7'-oxospiro(cyclopropane-1,3'(2'H)-(7H)pyrido(1,2,3-de)(1,4)benzoxazine)-6'-carboxylic acid [MeSH Supplementary Concept]
- 9-bromophenazine-4-carboxamide [MeSH Supplementary Concept]
- A 62176 [MeSH Supplementary Concept]
- A 85226 [MeSH Supplementary Concept]
- BE 10988 [MeSH Supplementary Concept]
- BE 13793C [MeSH Supplementary Concept]
- BE 22179 [MeSH Supplementary Concept]
- CJ 12371 [MeSH Supplementary Concept]
- CJ 12372 [MeSH Supplementary Concept]
- CJ 12373 [MeSH Supplementary Concept]
- FD 501 [MeSH Supplementary Concept]
- GL 331 [MeSH Supplementary Concept]
- GR 122222X [MeSH Supplementary Concept]
- Gatifloxacin [MeSH Descriptor]
- Gemifloxacin [MeSH Descriptor]
- Moxifloxacin [MeSH Descriptor]
- N,N-bis(3-(5-bromoacridine-4-carboxamido)propyl)methylamine [MeSH Supplementary Concept]
- N,N-bis(3-(5-methylacridine-4-carboxamido)propyl)methylamine [MeSH Supplementary Concept]
- N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide [MeSH Supplementary Concept]
- N-(2-(dimethylamino)ethyl)-2-(4-pyridyl)quinoline-8-carboxamide [MeSH Supplementary Concept]
- N-(2-(dimethylamino)ethyl)-5-methyl-4-acridinecarboxamide [MeSH Supplementary Concept]
- NSC 659687 [MeSH Supplementary Concept]
- PD 135042 [MeSH Supplementary Concept]
- PD 138312 [MeSH Supplementary Concept]
- PD 160793 [MeSH Supplementary Concept]
- PD 161148 [MeSH Supplementary Concept]
- PF 03376056 [MeSH Supplementary Concept]
- PNU-286607 [MeSH Supplementary Concept]
- SR 103 [MeSH Supplementary Concept]
- SR 107 [MeSH Supplementary Concept]
- UCT 1072M1 [MeSH Supplementary Concept]
- UCT 1072M2 [MeSH Supplementary Concept]
- VRT 125853 [MeSH Supplementary Concept]
- WCK 1734 [MeSH Supplementary Concept]
- WRC 213 [MeSH Supplementary Concept]
- aclarubicin [MeSH Descriptor]
- alatrofloxacin [MeSH Supplementary Concept]
- alpha-lapachone [MeSH Supplementary Concept]
- amifloxacin [MeSH Supplementary Concept]
- antofloxacin [MeSH Supplementary Concept]
- ardisin [MeSH Supplementary Concept]
- asulacrine [MeSH Supplementary Concept]
- azatoxin [MeSH Supplementary Concept]
- balofloxacin [MeSH Supplementary Concept]
- bastadin 14 [MeSH Supplementary Concept]
- besifloxacin [MeSH Supplementary Concept]
- bis(helenalinyl)glutarate [MeSH Supplementary Concept]
- bis(isoalantodiol-B)glutarate [MeSH Supplementary Concept]
- carbobenzoxycoumarin [MeSH Supplementary Concept]
- carubicin [MeSH Descriptor]
- chlorobiocic acid [MeSH Supplementary Concept]
- cinoxacin [MeSH Descriptor]
- ciprofloxacin [MeSH Descriptor]
- clinafloxacin [MeSH Supplementary Concept]
- coumermycin [MeSH Supplementary Concept]
- cyclothialidine [MeSH Supplementary Concept]
- daunorubicin [MeSH Descriptor]
- dexrazoxane [MeSH Descriptor]
- doxorubicin [MeSH Descriptor]
- eleutherin [MeSH Supplementary Concept]
- enoxacin [MeSH Descriptor]
- epirubicin [MeSH Descriptor]
- etirinotecan pegol [MeSH Supplementary Concept]
- etoposide [MeSH Descriptor]
- finafloxacin [MeSH Supplementary Concept]
- fleroxacin [MeSH Descriptor]
- flumequine [MeSH Supplementary Concept]
- garenoxacin [MeSH Supplementary Concept]
- grepafloxacin [MeSH Supplementary Concept]
- idarubicin [MeSH Descriptor]
- isoaurostatin [MeSH Supplementary Concept]
- kibdelomycin A [MeSH Supplementary Concept]
- leptosin F [MeSH Supplementary Concept]
- levofloxacin [MeSH Descriptor]
- lomefloxacin [MeSH Supplementary Concept]
- makaluvamine H [MeSH Supplementary Concept]
- makaluvamine I [MeSH Supplementary Concept]
- makaluvamine N [MeSH Supplementary Concept]
- matadine [MeSH Supplementary Concept]
- merbarone [MeSH Supplementary Concept]
- methyl 3-(4-(bis(2-chloroethyl)amino)phenyl)-2-(2-(4-((N-isopropyl)amidino)phenyl)furan-5-carboxamido)propanoate [MeSH Supplementary Concept]
- mitoxantrone [MeSH Descriptor]
- nadifloxacin [MeSH Supplementary Concept]
- nalidixic acid [MeSH Descriptor]
- neocryptolepine [MeSH Supplementary Concept]
- norfloxacin [MeSH Descriptor]
- novobiocin 401 [MeSH Supplementary Concept]
- ofloxacin [MeSH Descriptor]
- oxolinic acid [MeSH Descriptor]
- pazufloxacin [MeSH Supplementary Concept]
- pefloxacin [MeSH Descriptor]
- pixantrone [MeSH Supplementary Concept]
- prulifloxacin [MeSH Supplementary Concept]
- ro 47-3359 [MeSH Supplementary Concept]
- rufloxacin [MeSH Supplementary Concept]
- ruthenium ben [MeSH Supplementary Concept]
- ruthenium sal [MeSH Supplementary Concept]
- sitafloxacin [MeSH Supplementary Concept]
- sobuzoxane [MeSH Supplementary Concept]
- sparfloxacin [MeSH Supplementary Concept]
- temafloxacin [MeSH Supplementary Concept]
- teniposide [MeSH Descriptor]
- tridemethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine [MeSH Supplementary Concept]
- trovafloxacin [MeSH Supplementary Concept]
- ulifloxacin [MeSH Supplementary Concept]
- valrubicin [MeSH Supplementary Concept]
- zoliflodacin [MeSH Supplementary Concept]
UMLS correspondences (same concept)
- Topoisomerase-II Inhibitor [NCIt concept]

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