NCIt synonyms : Liposomal Cytarabine-Daunorubicin CPX-351; Cytarabine-Daunorubicin Liposome for Injection; Liposomal AraC-Daunorubicin CPX-351; Liposome-encapsulated Combination of Daunorubicin and Cytarabine; Liposomal Cytarabine-Daunorubicin;
NCIt related terms : Daunorubicin and Cytarabine (Liposomal); Cytarabine and daunorubicin liposomal;
NCIt definition : A liposomal formulation containing a fixed combination of the antineoplastic agents
cytarabine and daunorubicin in a 5:1 molar ratio. Liposome-encapsulated daunorubicin-cytarabine
has been designed to provide optimal delivery of a specific ratio of cytarabine to
daunorubicin, one that has been shown to be synergistic in vitro. The antimetabolite
cytarabine competes with cytidine for incorporation into DNA, inhibiting DNA synthesis.
This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication
and repair. Daunorubicin, an intercalator and a topoisomerase II inhibitor, prevents
DNA replication and inhibits protein synthesis. This agent also generates oxygen free
radicals, resulting in the cytotoxic lipid peroxidation of cell membrane lipids.;
Semantic type(s)