Preferred Label : Epirubicin Hydrochloride;
NCIt synonyms : 3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside
Hydrochloride; Epirubicin; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
Hydrochloride;
NCIt related terms : Ellence;
NCIt definition : The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic
doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby
inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.
This agent also produces toxic free-radical intermediates and interacts with cell
membrane lipids causing lipid peroxidation.;
Alternative definition : NCI-GLOSS: A drug used together with other drugs to treat early breast cancer that
has spread to lymph nodes. It is also being studied in the treatment of other types
of cancer. Ellence is a type of anthracycline antibiotic.;
UNII : 22966TX7J5;
InChIKey : MWWSFMDVAYGXBV-FGBSZODSSA-N;
CAS number : 56390-09-1;
Drug name : Pharmorubicin PFS; Ellence;
Molecule name : IMI-28;
Chemical formula : C27H29NO11.HCl;
NSC code : 256942;
Codes from synonyms : CDR0000523458; CDR0000523457;
Origin ID : C474;
UMLS CUI : C0700582;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
