Preferred Label : Epirubicin;
NCIt synonyms : 3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside; Epi DX; Epirubicin Base; 4'-epi DX; 4'-Epidoxorubicin; Epidoxorubicin; Pidorubicin; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
NCIt related terms : 4'-Epiadriamycin;
NCIt definition : A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin
intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication
and ultimately, interfering with RNA and protein synthesis. This agent also produces
toxic free-radical intermediates and interacts with cell membrane lipids causing lipid
peroxidation.;
Alternative definition : NCI-GLOSS: A drug used together with other drugs to treat early breast cancer that
has spread to lymph nodes. It is also being studied in the treatment of other types
of cancer. Epirubicin is a type of anthracycline antibiotic.;
UNII : 3Z8479ZZ5X;
InChIKey : AOJJSUZBOXZQNB-VTZDEGQISA-N;
CAS number : 56420-45-2;
Chemical formula : C27H29NO11;
ChEBI ID : CHEBI:47898;
Codes from synonyms : NSC0256942; CDR0000045194; 50534; 191;
Origin ID : C62028;
UMLS CUI : C0014582;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
