NCIt definition : A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is
selectively activated by multiple reductases to form free radicals in hypoxic cells,
thereby inducing single-and double-strand breaks in DNA, base damage, and cell death.
This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair
of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04);
Alternative definition : NCI-GLOSS: A drug that makes tumor cells more sensitive to radiation therapy.;
UNII : 1UD32YR59G;
InChIKey : ORYDPOVDJJZGHQ-UHFFFAOYSA-N;
CAS number : 27314-97-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 27314-97-2
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