Tirapazamine - CISMeF

Preferred Label : Tirapazamine;

NCIt synonyms : 3-Amino-1,2,4-benzotriazine-1,4-dioxide;

NCIt definition : A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04);

Alternative definition : NCI-GLOSS: A drug that makes tumor cells more sensitive to radiation therapy.;

UNII : 1UD32YR59G;

InChIKey : ORYDPOVDJJZGHQ-UHFFFAOYSA-N;

CAS number : 27314-97-2;

Drug name : Tirazone;

Molecule name : WIN-59075; SR 4233; WIN 59075; SR-4233;

Chemical formula : C7H6N4O2;

NSC code : 130181;

Codes from synonyms : CDR0000045427; 111602;

Details

Origin ID

C1464;

UMLS CUI

C0208407;

Currated CISMeF NLP mapping
- Tirapazamine [MeSH Descriptor]
- tirapazamine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tirapazamine [MeSH Descriptor]
- tirapazamine [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Free Radical Formation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- DNA Replication Inhibition [NCIt concept]
- DNA Strand Break [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]
- Topoisomerase II [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Paclitaxel/Tirapazamine [NCIt concept]
- Cisplatin/Etoposide/Tirapazamine [NCIt concept]
- Cisplatin/Fluorouracil/Tirapazamine [NCIt concept]
- Cisplatin/Paclitaxel/Tirapazamine [NCIt concept]
- Cisplatin/Tirapazamine [NCIt concept]
- Cisplatin/Tirapazamine/Vinorelbine [NCIt concept]
- Cyclophosphamide/Doxorubicin/Tirapazamine [NCIt concept]
- Cyclophosphamide/Tirapazamine [NCIt concept]

Keyword's position in hierarchy(ies) :

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