Tirapazamine - CISMeF

Preferred Label : Tirapazamine;

MeSH definition : A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.;

MeSH synonym : 3-Amino-1,2,4-benzotriazine-1,4-dioxide;

MeSH hyponym : WIN-59075; WIN59075; SR-4233; SR4233;

MeSH CAS label : 1,2,4-Benzotriazin-3-amine, 1,4-dioxide;

MeSH Related Number : 27314-97-2 (Tirapazamine);

Wikipedia link : https://en.wikipedia.org/wiki/Tirapazamine;

UNII : 1UD32YR59G;

Details

Origin ID

D000077704;

UMLS CUI

C0208407;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Tirapazamine [NCIt concept]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- radiation-sensitizing agents [MeSH Descriptor]
Record concept(s)
- NSC 130181 [MeSH concept]
- SR 4233 [MeSH concept]
- WIN 59075 [MeSH concept]
- tirapazamine [MeSH concept]
- tirazone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tirapazamine [NCIt concept]

Keyword's position in hierarchy(ies) :

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