Preferred Label : Idarubicin;
NCIt synonyms : 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside; 4-DMDR;
NCIt definition : A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic
daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of
topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein
synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more
efficiently than other anthracycline antibiotic compounds.;
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antitumor
antibiotics.;
UNII : ZRP63D75JW;
InChIKey : XDXDZDZNSLXDNA-TZNDIEGXSA-N;
CAS number : 58957-92-9;
Chemical formula : C26H27NO9;
ChEBI ID : CHEBI:42068;
Codes from synonyms : CDR0000045254; CDR0000044413; 265;
Origin ID : C562;
UMLS CUI : C0020789;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
