Idarubicin Hydrochloride

Preferred Label : Idarubicin Hydrochloride;

NCIt synonyms : Idarubicin HCl;

NCIt definition : The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds;

UNII : 5VV3MDU5IE;

InChIKey : JVHPTYWUBOQMBP-RVFAQHLVSA-N;

CAS number : 57852-57-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 57852-57-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zavedos; Idamycin; Idamycin PFS;

Molecule name : IMI-30; SC-33428;

Chemical formula : C26H27NO9.HCl;

NSC code : 256439;

Codes from synonyms : NSC0256439;

Details

Origin ID

C1587;

UMLS CUI

C0282388;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- idarubicin [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Idarubicin [NCIt concept]
has_target
- Topoisomerase II [NCIt concept]
is_component_of_chemotherapy_regimen
- Clofarabine/Cytarabine/Idarubicin Regimen [NCIt concept]
- Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine Regimen [NCIt concept]
- Cyclophosphamide/Cytarabine/Daunorubicin/Idarubicin/Pegaspargase/Prednisone/Vincristine Regimen [NCIt concept]
- Cytarabine/Idarubicin Regimen [NCIt concept]
- High-dose Cytarabine/Idarubicin Regimen [NCIt concept]
is_salt_form_of
- Idarubicin [NCIt concept]

Keyword's position in hierarchy(ies) :

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