Preferred Label : Mitoxantrone;
NCIt synonyms : Mitozantrone; Dihydroxyanthracenedione; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone; 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione; Mitoxantrone Base;
NCIt definition : An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates
into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also
binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair.
Mitoxantrone is less cardiotoxic compared to doxorubicin.;
Alternative definition : NCI-GLOSS: A drug used to treat advanced prostate cancer that does not respond to
hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis.
It is also being studied in the treatment of other cancers. It belongs to the family
of drugs called antitumor antibiotics.;
UNII : BZ114NVM5P;
InChIKey : KKZJGLLVHKMTCM-UHFFFAOYSA-N;
CAS number : 65271-80-9;
Chemical formula : C22H28N4O6;
NSC code : 279836;
ChEBI ID : CHEBI:50729;
Codes from synonyms : NSC0301739; CDR0000045192; 336;
Origin ID : C62050;
UMLS CUI : C0026259;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
