Preferred Label : Doxorubicin Prodrug/Prodrug-activating Biomaterial SQ3370;
NCIt synonyms : SQL70-SQP33; Doxorubicin Prodrug SQP33/Prodrug-activating Biomaterial SQL7; SQL70/SQP33;
NCIt definition : A formulation consisting of SQL70, a prodrug-activating biomaterial, and SQP33, a
prodrug of the anthracycline antineoplastic antibiotic doxorubicin, with potential
antineoplastic activity. Upon administration of SQ3370, which consists of the injection
of SQL70 at the tumor site followed by the intravenous administration of SQ3370, the
prodrug SQP33 binds to, through an as of yet not identifiable mechanism, to SQL70
at the tumor site. After binding, doxorubicin is released over a period of days, intercalates
into DNA and interacts with topoisomerase II. This leads to an inhibition of DNA replication
and repair, and prevents RNA and protein synthesis. Compared to the systemic administration
of doxorubicin alone, SQ3370 may allow for higher and sustained delivery of active
doxorubicin directly to the tumor, which may increase its efficacy and limit its off-site,
systemic toxicity.;
Molecule name : SQ-3370; SQ 3370;
NCI Metathesaurus CUI : CL972446;
Origin ID : C167221;
UMLS CUI : C5238374;
Semantic type(s)
- concept_is_in_subset
- has_target
