Preferred Label : Micro Needle Array-Doxorubicin;
NCIt synonyms : Doxorubicin-loaded Patches; MNA-D Patches; Micro-needle Array Doxorubicin; MNA-Doxorubicin; MNA-D; Microneedle Applicator-Doxorubicin; Doxorubicin-coated Patches; Microneedle Array Doxorubicin; Dissolvable Microneedles-containing Doxorubicin; D-MNA;
NCIt definition : A formulation composed of dissolvable small, adhesive-like patches composed of a biocompatible
material which is coated with the anthracycline antibiotic doxorubicin, with potential
antineoplastic and immunomodulating activities. Upon cutaneous administration of the
microneedle-array-doxorubicin, the microneedles degrade once inserted into the skin
and doxorubicin is released from the dissolvable microneedle array delivery device
directly into the tumor microenvironment (TME). Doxorubicin is taken up by tumor cells
and intercalates into DNA and interferes with topoisomerase II activity. This inhibits
DNA replication and RNA synthesis, leading to tumor cell growth inhibition and apoptosis.
This agent also interacts with cell membrane lipids causing lipid peroxidation. In
addition, doxorubicin induces innate, adaptive, and tumor-specific effector and memory
immune responses, thereby further killing the tumor cells. Delivery of doxorubicin
using the microneedle array delivery system allows direct and specific administration
of doxorubicin to the TME which may improve drug concentration into tumor cells and
may reduce systemic toxicity, compared to the administration of systemic doxorubicin
alone.;
NCI Metathesaurus CUI : CL935685;
Origin ID : C156665;
UMLS CUI : C4744969;
Semantic type(s)
- concept_is_in_subset
- has_target
