NCIt definition : A synthetic 9-amino-anthracycline with antineoplastic activity. Amrubicin intercalates
into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of
DNA replication, and RNA and protein synthesis, followed by cell growth inhibition
and cell death. This agent has demonstrated a higher level of anti-tumor activity
than conventional anthracycline drugs without exhibiting any indication of the cumulative
cardiac toxicity common to this class of compounds.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of lung cancer. It is a type
of anthracycline analog.;