Pegylated Liposomal Doxorubicin Hydrochloride

Preferred Label : Pegylated Liposomal Doxorubicin Hydrochloride;

NCIt synonyms : Pegylated Doxorubicin HCl Liposome; Stealth Liposomal Doxorubicin; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride; Liposomal-Encapsulated Doxorubicin; Liposomal Adriamycin; S-Liposomal Doxorubicin; Doxorubicin HCl Liposome; Doxorubicin Hydrochloride Liposome; Doxorubicin HCl Liposomal;

NCIt related terms : DOXIL; LipoDox; liposomal doxorubicin hydrochloride; Dox-SL; Evacet; Pegylated liposomal doxorubicin;

NCIt definition : A liposome-encapsulated preparation of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Doxorubicin intercalates between DNA base pairs, thereby hinders the movement of replication machinery along DNA strands, as well as blocks the activity of topoisomerase II during replication. As a result, this agent causes DNA adducts formation, renders single- and double-stranded DNA breakages that induce DNA repair and or apoptotic processes. Doxorubicin also generates reactive oxygen species that leads to cytotoxicity secondary to lipid peroxidation of cell membrane lipids. Liposomal delivery of doxorubicin HCl improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. A liposomal formulation of doxorubicin also modulates toxicity, specifically the cardiac effects commonly seen with anthracycline antitumor drugs.;

Alternative definition : NCI-GLOSS: A form of the anticancer drug doxorubicin that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than doxorubicin. Doxil is used to treat ovarian cancer, AIDS-related Kaposi sarcoma, and multiple myeloma in patients whose disease has not gotten better after treatment with other anticancer drugs. It may be used together with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Doxil is a type of anthracycline antitumor antibiotic.;

Drug name : Caelyx; Evacet; Doxil; LipoDox; Doxilen; DOX-SL; Duomeisu; Lipodox 50;

Molecule name : TLC D-99; ATI-0918;

NSC code : 712227;

Codes from synonyms : CDR0000663502; NSC0712227; CDR0000560137; CDR0000560138; CDR0000560136; CDR0000560139; CDR0000512797; 393;

Details

Origin ID

C1555;

UMLS CUI

C1522690;

Automatic exact mappings (from CISMeF team)
- DOX-SL [MeSH concept]
- caelyx [MeSH concept]
- doxil [MeSH concept]
- liposomal doxorubicin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Doxorubicin hydrochloride pegylated liposome (substance) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Daunorubicin hydrochloride liposome (substance) [SNOMED CT concept]
- Doxorubicin hydrochloride pegylated liposome (substance) [SNOMED CT concept]
Validated automatic mappings to NTBT
- Daunorubicin hydrochloride liposome (substance) [SNOMED CT concept]
- doxorubicin [MeSH Descriptor]
- doxorubicin [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Topoisomerase II [NCIt concept]
is_component_of_chemotherapy_regimen
- Bevacizumab/Caroplatin/Liposomal Doxorubicin Regimen [NCIt concept]
- Bevacizumab/Liposomal Doxorubicin Regimen [NCIt concept]
- Bortezomib/Dexamethasone/Pegylated Liposomal Doxorubicin Regimen [NCIt concept]
- Bortezomib/Liposomal Doxorubicin Regimen [NCIt concept]
- CVDD Regimen [NCIt concept]
- Carboplatin/Doxorubicin HCl Liposome [NCIt concept]
- Carboplatin/Doxorubicin HCl Liposome/Paclitaxel [NCIt concept]
- Carboplatin/Doxorubicin Hydrochloride Liposome [NCIt concept]
- Carboplatin/Liposomal Doxorubicin Regimen [NCIt concept]
- Cisplatin/Doxorubicin Hydrochloride Liposome/Mitomycin [NCIt concept]
- Cisplatin/Doxorubicin Hydrochloride Liposome/Paclitaxel [NCIt concept]
- Cyclophosphamide/Doxorubicin HCl Liposome/Prednisone/Vincristine [NCIt concept]
- Dexamethasone/Liposomal Doxorubicin/Etoposide/Ibrutinib/Rituximab/Temozolomide Regimen [NCIt concept]
- Dexamethasone/Liposomal Doxorubicin/Etoposide/Rituximab/Temozolomide Regimen [NCIt concept]
- Dexamethasone/Liposomal Doxorubicin/Vincristine Regimen [NCIt concept]
- Docetaxel/Doxorubicin HCl Liposome [NCIt concept]
- Docetaxel/Doxorubicin Hcl Liposome/Trastuzumab [NCIt concept]
- Doxorubicin HCl Liposome/Etoposide [NCIt concept]
- Doxorubicin HCl Liposome/PSC 833 [NCIt concept]
- Doxorubicin HCl Liposome/Paclitaxel [NCIt concept]
- Doxorubicin HCl Liposome/Topotecan [NCIt concept]
- Doxorubicin HCl Liposome/VX-853 [NCIt concept]
- Doxorubicin Hcl Liposome/Gemcitabine [NCIt concept]
- Doxorubicin Hcl Liposome/Gemcitabine/Vinorelbine [NCIt concept]
- Doxorubicin Hcl Liposome/Ifosfamide [NCIt concept]
- Doxorubicin Hcl Liposome/Interleukin-12 [NCIt concept]
- Doxorubicin Hcl Liposome/Methotrexate/Prednisone/Vincristine [NCIt concept]
- Doxorubicin Hcl Liposome/ZD0473 [NCIt concept]
- GVD Regimen [NCIt concept]
- GVD/Pembrolizumab Regimen [NCIt concept]
- Liposomal Doxorubicin Regimen [NCIt concept]
- Liposomal Doxorubicin/Ganciclovir Regimen [NCIt concept]
- Liposomal Doxorubicin/Gemcitabine Regimen [NCIt concept]
- Liposomal Doxorubicin/Pomalidomide Regimen [NCIt concept]
- Liposomal Doxorubicin/Valganciclovir Regimen [NCIt concept]
- Pegylated Liposomal Doxorubicin/Trastuzumab Regimen [NCIt concept]
- R-CDOP Regimen [NCIt concept]
- R-GVD Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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