Preferred Label : Patupilone;
NCIt synonyms : (-)-Epothilone B; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;
NCIt related terms : epothilone B; EPO906;
NCIt definition : A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel,
patupilone induces microtubule polymerization and stabilizes microtubules against
depolymerization conditions. In addition to promoting tubulin polymerization and stabilization
of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein,
a characteristic that distinguishes it from the taxanes. Patupilone may cause complete
cell-cycle arrest.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of epothilone.;
UNII : UEC0H0URSE;
InChIKey : QXRSDHAAWVKZLJ-PVYNADRNSA-N;
CAS number : 152044-54-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 152044-54-7
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G-SRS /a ;
Molecule name : EPO-906A;
Chemical formula : C27H41NO6S;
Codes from synonyms : 50591; CDR0000269417; CDR0000269416;
Origin ID : C1623;
UMLS CUI : C0297960;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
- has_target
