Canalicular Multispecific Organic Anion Transporter 1

Preferred Label : Canalicular Multispecific Organic Anion Transporter 1;

NCIt synonyms : Canalicular Multidrug Resistance Protein; ATP-Binding Cassette Sub-Family C Member 2; Multidrug Resistance-Associated Protein 2; ABCC2;

NCIt definition : Canalicular multispecific organic anion transporter 1 (1545 aa, 174 kDa) is encoded by the human ABCC2 gene. This protein is involved in both anion transport and multidrug resistance.;

NCIt note : Substrates for canalicular multispecific organic anion transporter 1 may include vinblastine and cisplatin.;

Détails

Origin ID

C103884;

UMLS CUI

C3540577;

OMIM relation
- Atp-binding cassette, subfamily C, member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABCC2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Multidrug Resistance Gene [NCIt concept]
- Translocase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hepatic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Apical Domain of the Epithelium [NCIt concept]
- Cellular Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Permease [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- ABC Transporter Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Drug Efflux [NCIt concept]
- Drug Transport Process [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Transport Process [NCIt concept]

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