" /> Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Mitochondrial - CISMeF





Preferred Label : Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Mitochondrial;

NCIt synonyms : EC 3.6.1.23; dUTP Pyrophosphatase; dUTP Diphosphatase; Deoxyuridine Triphosphate Nucleotidohydrolase; DUT-M; DUT; dUTPase; Deoxyuridine Triphosphatase; dUTP Nucleotidohydrolase;

NCIt definition : Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (252 aa, 27 kDa) is encoded by the human DUT gene. This protein is involved in uracil and thymidine metabolism.;

NCIt note : DUT encodes a mitochondrial form (DUT-M) and a nuclear form (DUT-N), which are non-identical isoforms produced by alternative splicing. The canonical form in UniProt is DUT-M. The N-terminal region of DUT-M contains an arginine-rich, 69-residue mitochondrial targeting sequence that is not found in the DUT-N isoform. DUT-M is constitutively expressed throughout the cell cycle, but DUT-N expression is tightly regulated to coincide with the cessation of nuclear DNA replication. (OMIM and UniProt);

NCI Metathesaurus CUI : CL1771389;

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28/04/2024


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