Dynamin-Like 120 kDa Protein, Mitochondrial

Preferred Label : Dynamin-Like 120 kDa Protein, Mitochondrial;

NCIt synonyms : OPA1; Optic Atrophy Protein 1; OPA1 Mitochondrial Dynamin-Like GTPase; OPA1 Mitochondrial Dynamin Like GTPase; Mitochondrial Dynamin-Like GTPase; Dynamin-Like Guanosine Triphosphatase; EC 3.6.5.5;

NCIt definition : Dynamin-like 120 kDa protein, mitochondrial (960 aa, 112 kDa) is encoded by the human OPA1 gene. This protein plays a role in GTPase activity that regulates fusion and fission of mitochondria.;

Details

Origin ID

C186736;

UMLS CUI

C0961738;

Automatic exact mappings (from CISMeF team)
- OPA1 mitochondrial dynamin like GTPase [HGNC gene]
- OPA1 mitochondrial dynamin like GTPase [ORDO Gene]
- Opa1 mitochondrial dynamin-like gtpase [OMIM gene]
- Optic atrophy 1 [OMIM Phenotype]
- mediator complex subunit 12 [ORDO Gene]
OMIM relation
- Opa1 mitochondrial dynamin-like gtpase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- OPA1 protein, human [MeSH Supplementary Concept]
- OPA1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- OPA1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Inner Mitochondrial Membrane [NCIt concept]
- Mitochondrion [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
- Mitochondrial Membrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- GTP Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Process [NCIt concept]
- GTP Binding [NCIt concept]
- Hydrolysis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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