Preferred Label : Coiled-Coil Domain;
NCIt synonyms : Coiled Coil Domain; 4-3 Hydrophobic Repeat; Left-Handed Twist; Coiled-Coil; Coiled Coil;
NCIt definition : A domain that stabilizes alpha helices in proteins through a very efficient burial
of hydrophobic side chains so that polar water molecules do not access them. As a
result, the helices are quite stable. In fact, many structural proteins (keratins,
tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain.
Two basic essential features are common: (1) the overall secondary structure is alpha
helical, (2) the hydrophobic residues are arranged on one side of the helices. The
typical positioning of the hydrophobic residues in the coiled-coil domain can be often
recognized from primary structure of the protein. The helices can be parallel or antiparallel.
The former is common when the helices belong to different polypeptides and the latter
prevails in coiled coils made up from a single polypeptide chain. The number of helices
in the coil varies usually between 2 and 4.;
Origin ID : C13967;
UMLS CUI : C1516692;
Associated anatomy of gene products
- Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
