SARS-CoV-2 Spike Protein S1

Preferred Label : SARS-CoV-2 Spike Protein S1;

NCIt synonyms : SARS2 Spike Protein S1; Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein S1; Spike Protein S1; Spike 1; S1 Subunit;

NCIt related terms : S1;

NCIt definition : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein 1 (672 aa, 75 kDa) is encoded by the SARS-CoV-2 S gene. This protein plays a role in binding to host cell membranes and the initiation of viral infection.;

NCIt note : SARS-CoV-2 spike glycoprotein is sequentially cleaved to form spike protein S1 (amino acid residues 13-685), spike protein S2 (residues 686-1273) and spike protein S2' (residues 816-1273). S1 binds to angiotensin-converting enzyme 2, while S2 and S2' mediate fusion of the virion and cellular membranes. (UniProt);

NCI Metathesaurus CUI : CL1794635;

Details

Origin ID

C188487;

UMLS CUI

C5707811;

Automatic exact mappings (from CISMeF team)
- S1 subunit [COVID-19 Thesaurus concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
- SeroNet Authorized Values [NCIt concept]
- SeroNet Study Descriptors [NCIt concept]
gene_encodes_gene_product
- SARS-CoV-2 S Gene [NCIt concept]
- Viral Gene [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Virus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- SARS-CoV-2 N-Terminal Domain [NCIt concept]
- SARS-CoV-2 Spike Receptor Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Receptor Binding [NCIt concept]
- Virus-Cell Membrane Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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