Protein CASC3 - CISMeF

Preferred Label : Protein CASC3;

NCIt synonyms : Metastatic Lymph Node 51 Protein; MLN51; CASC3; MLN51 Protein;

NCIt definition : Protein CASC3 (703 aa, 76 kDa) is encoded by the human CASC3 gene. This protein plays a role in RNA binding and metabolism.;

NCIt note : The N-terminal half of protein CASC3 contains putative nuclear localization signals and a coiled-coil domain, which seems to promote oligomerization, while the C-terminal half contains one SH2- and four SH3-binding motifs and may regulate nuclear localization.;

Details

Origin ID

C21525;

UMLS CUI

C1137611;

OMIM relation
- Cancer susceptibility candidate 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CASC3 protein, human [MeSH concept]
- CASC3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CASC3 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- SH2-Binding Motif [NCIt concept]
- SH3-Binding Motif [NCIt concept]
gene_product_malfunction_associated_with_disease
- Breast Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Processing [NCIt concept]
- Transport Process [NCIt concept]
- mRNA Export [NCIt concept]

Keyword's position in hierarchy(ies) :

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