Preferred Label : SH2-Binding Motif;
NCIt synonyms : SH2-Binding Domain;
NCIt definition : Typically found in signaling proteins, the SH2-Binding Motif mediates regulated high-affinity
physical interaction (binding) with the target SH2 (SRC Homology 2) domain. SH2 domains
of 100 amino acids bind to specific phosphotyrosine (pY)-containing motifs with dissociation
constants of 50-500 nM. A conserved pocket of SH2 domains recognizes the pY, and
a more variable pocket binds residues C-terminal to pY that confer specificity. SH2
domains balance high affinity for pY and recognition of adjacent residues to allow
specific discrimination. The SH2 domain, an anti-parallel b-sheet between a-helices,
provides a positively charged b-sheet pocket for binding of pY moieties, and an extended
b-sheet surface for binding residues C-terminal to pY. B-sheet surface differences
have significant effects on ligand-specificity. (NCI);
Origin ID : C14108;
UMLS CUI : C1519140;
Currated CISMeF NLP mapping
- Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
