SH3-Binding Motif

Preferred Label : SH3-Binding Motif;

NCIt synonyms : SH3-Binding Domain;

NCIt definition : Typically found in proteins involved in signaling pathways, the SH3-Binding Motif is a peptide sequence that mediates regulated high-affinity physical interaction (binding) with the SH3 (SRC Homology 3) domain in target protein partners. The SH3-binding motif often share proline-rich stretches containing a common PXXP motif. (NCI);

Details

Origin ID

C14109;

UMLS CUI

C1519141;

Currated CISMeF NLP mapping
- SH3 domain binding [GO term]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- Auxilin [NCIt concept]
- Citron Rho-Interacting Kinase [NCIt concept]
- Coiled-Coil Domain-Containing Protein 6 [NCIt concept]
- Contactin-Associated Protein 1 [NCIt concept]
- GRB2-Associated-Binding Protein 2 [NCIt concept]
- PR Domain Zinc Finger Protein 2 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Phospholipid Scramblase 1 [NCIt concept]
- Protein CASC3 [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Ras/Rap GTPase-Activating Protein SynGAP [NCIt concept]
- SH3 and Multiple Ankyrin Repeat Domains Protein 2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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