PR Domain Zinc Finger Protein 2

Preferred Label : PR Domain Zinc Finger Protein 2;

NCIt synonyms : PR Domain-Containing Protein 2; Retinoblastoma Protein-Binding Zinc Finger Protein; EC 2.1.1.43; MTE-Binding Protein; Retinoblastoma Protein-Binding Zinc Finger Protein RIZ; Lysine N-Methyltransferase 8; GATA-3-Binding Protein G3B; Retinoblastoma Protein-Interacting Zinc Finger Protein; MTB-ZF; Zinc-Finger DNA-Binding Protein; PRDM2; Zinc Finger Protein RIZ; GATA-3 Binding Protein G3B;

NCIt definition : PR domain zinc finger protein 2 (1718 aa, 189 kDa) is encoded by the human PRDM2 gene. This protein is involved in both transcriptional regulation and the methylation of histone H3.;

NCIt note : PR domain zinc finger protein 2 binds to retinoblastoma protein, estrogen receptor, and the macrophage-specific tetradecanoylphorbol acetate (TPA)-responsive element (MTE) of the heme-oxygenase-1 gene. (EntrezGene);

Details

Origin ID

C143123;

UMLS CUI

C0297511;

Automatic exact mappings (from CISMeF team)
- PR/SET domain 2 [HGNC gene]
- Pr domain-containing protein 2 [OMIM gene]
OMIM relation
- Pr domain-containing protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PRDM2 protein, human [MeSH Supplementary Concept]
- PRDM2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- PRDM2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
- Proline-Rich Domain [NCIt concept]
- SET Domain [NCIt concept]
- SH3-Binding Motif [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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