Preferred Label : SET Domain;
NCIt definition : SET domains appear to be protein-protein interaction domains. SET domains mediate
interactions with a family of proteins that display similarity with dual-specificity
phosphatases (dsPTPases). The SET domain genes are widely represented in the eukaryotic
genomes. Proteins bearing the widely distributed SET domain (ca. 130 amino acid) contribute
to epigenetic mechanisms of gene regulation by methylation of lysine residues in histones
and other proteins. The SET domain appears generally as one part of a larger multidomain
protein. It appears that the varied domains that occur together with the SET domain
are involved in recognizing protein substrates and ''reading'' histone tails in order
to dictate which (if any) of their multiple lysine residues should get methylated.
(From Pfam PF00856);
Origin ID : C14093;
UMLS CUI : C1519134;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
