Histone-Lysine N-Methyltransferase SETD1B

Preferred Label : Histone-Lysine N-Methyltransferase SETD1B;

NCIt synonyms : Lysine N-Methyltransferase 2G; SETD1B; SET1B; EC 2.1.1.43; Lysine-Specific Methyltransferase 2G; hSET1B;

NCIt definition : Histone-lysine N-methyltransferase SETD1B (1966 aa, 213 kDa) is encoded by the human SETD1B gene. This protein is involved in catalyzing the methylation of lysine-4 in histone H3.;

NCIt note : Methylation of lysine-4 of histone H3 by histone-lysine N-methyltransferase SETD1B is inhibited if lysine-9 of histone H3 is methylated. (UniProt);

NCI Metathesaurus CUI : CL540225;

Details

Origin ID

C142223;

UMLS CUI

C4549927;

Automatic exact mappings (from CISMeF team)
- SET domain containing 1B, histone lysine methyltransferase [ORDO Gene]
- Set domain-containing protein 1b [OMIM gene]
OMIM relation
- Set domain-containing protein 1b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SETD1B protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- SETD1B Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Proline-Rich Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
- SET Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Gene Expression [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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