Histone-Lysine N-Methyltransferase KMT5C

Preferred Label : Histone-Lysine N-Methyltransferase KMT5C;

NCIt synonyms : H4-K20-HMTase SUV420H2; EC 2.1.1.43; Su(var)4-20 Homolog 2; Suv4-20h2; Lysine-Specific Methyltransferase 5C; KMT5C; Suppressor of Variegation 4-20 Homolog 2; Histone-Lysine N-Methyltransferase SUV420H2; Lysine N-Methyltransferase 5C;

NCIt definition : Histone-lysine N-methyltransferase KMT5C (462 aa, 52 kDa) is encoded by the human KMT5C gene. This protein may play a role in transcriptional repression and in the establishment of pericentric heterochromatin domains.;

NCIt note : Histone-lysine N-methyltransferase KMT5C specifically trimethylates the lysine at amino acid position 20 in histone H4. (UniProt);

Details

Origin ID

C73700;

UMLS CUI

C2743825;

OMIM relation
- Lysine methyltransferase 5c [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KMT5C protein, human [MeSH concept]
- KMT5C protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- KMT5C Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Heterochromatin [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- SET Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Gene Regulation Process [NCIt concept]
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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