Histone-Lysine N-Methyltransferase MECOM

Preferred Label : Histone-Lysine N-Methyltransferase MECOM;

NCIt synonyms : Ecotropic Virus Integration Site 1 Protein Homolog; EVI-1; Myelodysplasia Syndrome 1 Protein; MDS1 and EVI1 Complex Locus Protein; Myelodysplasia Syndrome-Associated Protein 1; Ecotropic Virus Integration 1 Site Protein; MECOM; EC 2.1.1.367;

NCIt definition : Histone-lysine N-methyltransferase MECOM (1230 aa, 138 kDa) is encoded by the human MECOM gene. This protein plays a role in monomethylation of lysine-9 in histone H3 (H3K9me1).;

NCI Metathesaurus CUI : CL1378685;

Details

Origin ID

C168786;

UMLS CUI

C5239119;

OMIM relation
- Mds1 and evi1 complex locus [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MECOM protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MECOM Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- SET Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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