Histone-Lysine N-Methyltransferase 2B

Preferred Label : Histone-Lysine N-Methyltransferase 2B;

NCIt synonyms : Myeloid/Lymphoid Or Mixed-Lineage Leukemia 4; Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 4; Trithorax Homologue 2; EC 2.1.1.43; Lysine-Specific Methyltransferase 2B; WW Domain Binding Protein 7; MLL4; Lysine N-Methyltransferase 2B; WBP-7; WW Domain-Binding Protein 7; Histone-Lysine N-Methyltransferase MLL4; Trithorax Homolog 2; KMT2B;

NCIt definition : Histone-lysine N-methyltransferase 2B (2715 aa, 294 kDa) is encoded by the human KMT2B gene. This protein is involved in epigenetic transcriptional activation through the mediation of histone methylation.;

Details

Origin ID

C115964;

UMLS CUI

C3888275;

Automatic exact mappings (from CISMeF team)
- Lysine-specific methyltransferase 2b [OMIM gene]
- Lysine-specific methyltransferase 2d [OMIM gene]
- lysine methyltransferase 2B [HGNC gene]
- lysine methyltransferase 2B [ORDO Gene]
- lysine methyltransferase 2D [ORDO Gene]
OMIM relation
- Lysine-specific methyltransferase 2b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- KMT2B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- KMT2B Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- AT Hook Motif [NCIt concept]
- PHD Finger [NCIt concept]
- SET Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Histone Methylation [NCIt concept]
- Methylation [NCIt concept]
- Oogenesis [NCIt concept]
- Ovulation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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