AT Hook Motif - CISMeF

Preferred Label : AT Hook Motif;

NCIt synonyms : AT Hook Domain; ATH;

NCIt definition : Highly conserved peptide motifs of the HMG-I(Y) proteins that preferentially bind to the AT-rich minor groove of DNA. The AT hook motif tethers and unwinds the minor groove of the DNA with very little specificity for the DNA sequence. The AT hook motif has a narrow DNA recognition surface that is devoid of hydrophobic amino acids and that does not significantly distort the B-form DNA structure.;

Details

Origin ID

C13741;

UMLS CUI

C0949662;

Automatic exact mappings (from CISMeF team)
- arthroplasty, replacement, hip [MeSH Descriptor]
Currated CISMeF NLP mapping
- AT-Hook motifs [MeSH concept]
- at-hook motifs [MeSH Descriptor]
False automatic mappings
- Atherosclerosis susceptibility [OMIM Phenotype]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- AT-Hook motifs [MeSH concept]
- at-hook motifs [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- AT-Hook-Containing Transcription Factor [NCIt concept]
- HMGA Family Protein [NCIt concept]
- High Mobility Group Protein HMG-I [NCIt concept]
- High Mobility Group Protein HMG-R [NCIt concept]
- High Mobility Group Protein HMG-Y [NCIt concept]
- High-Mobility Group Protein HMGI-C [NCIt concept]
- Histone-Lysine N-Methyltransferase 2A [NCIt concept]
- Histone-Lysine N-Methyltransferase 2B [NCIt concept]
- Histone-Lysine N-Methyltransferase 2C [NCIt concept]
- PHD Finger Protein 20 [NCIt concept]
- POZ-, AT Hook-, and Zinc Finger-Containing Protein 1 [NCIt concept]
- SET-Binding Protein [NCIt concept]
- Transcription Factor Gibbin [NCIt concept]

Keyword's position in hierarchy(ies) :

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