High Mobility Group Protein HMG-Y

Preferred Label : High Mobility Group Protein HMG-Y;

NCIt synonyms : HMG Y; HMG-Y; High Mobility Group Protein HMG Isoform HMG-Y; High Mobility Group Protein A1b; HMGY; HMGA1b; High Mobility Group AT-Hook 1b; High Mobility Group AT-Hook Protein 1b; HMGA1;

NCIt definition : High mobility group protein HMG-Y (96 aa, 11 kDa) is encoded by the human HMGA1 gene. This protein is involved in transcriptional modulation and chromatin remodeling.;

NCIt note : HMGA1b, encoded by the HMGA1 gene, preferentially binds to the minor groove of A T-rich regions in double-stranded DNA. It is involved in transcriptional regulation of the BRCA1 gene. HMGA1b overexpression accounts for BRCA1 downregulation in sporadic breast carcinomas. (From PubMed 12640109 and NCI);

Details

Origin ID

C20323;

UMLS CUI

C5441629;

Automatic exact mappings (from CISMeF team)
- HMGA1b protein [MeSH concept]
- High mobility group at-hook 1 [OMIM gene]
- hmga1b protein [MeSH Descriptor]
OMIM relation
- High mobility group at-hook 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HMGA1b protein [MeSH concept]
- hmga1b protein [MeSH Descriptor]
gene_encodes_gene_product
- HMGA1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_abnormality
- Protein Deregulation [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- HMGA Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- AT Hook Motif [NCIt concept]
gene_product_is_element_in_pathway
- IL4-Mediated Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Sporadic Breast Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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