HMGA Family Protein

Preferred Label : HMGA Family Protein;

NCIt synonyms : HMG-I/Y Protein; HMG-I(Y) Protein; HMG-I/Y/C; HMGI(Y) Protein; AT-Hook Protein; High Mobility Group A Protein;

NCIt definition : Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81);

Details

Origin ID

C20325;

UMLS CUI

C2752101;

Automatic exact mappings (from CISMeF team)
- HMGA1a protein [MeSH concept]
- high mobility group proteins [MeSH Descriptor]
- high mobility group proteins [MeSH concept]
- hmga1a protein [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- HMG Family Gene [NCIt concept]
- HMGA Family Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- AT Hook Motif [NCIt concept]
- DNA Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_chemical_classification_of_gene_product
- High Mobility Group Protein HMG-I [NCIt concept]
- High Mobility Group Protein HMG-R [NCIt concept]
- High Mobility Group Protein HMG-Y [NCIt concept]
- High-Mobility Group Protein HMGI-C [NCIt concept]

Keyword's position in hierarchy(ies) :

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