High Mobility Group Protein HMG-I

Preferred Label : High Mobility Group Protein HMG-I;

NCIt synonyms : HMG-I; HMGI; HMGA1a; High Mobility Group Protein HMG Isoform HMG-I; High Mobility Group AT-Hook 1a; HMG I; High Mobility Group AT-Hook Protein 1; High Mobility Group AT-Hook Protein 1a; HMG-I/Y; High Mobility Group Protein A1; High Mobility Group Protein A1a;

NCIt related terms : HMGA1;

NCIt definition : High mobility group protein HMG-I (107 aa, 12 kDa) is encoded by the human HMGA1 gene. This protein plays a role in the regulation of both transcription and chromatin structure.;

Alternative definition : NCI-GLOSS: A protein that binds to the DNA and certain proteins in chromosomes. It is involved in many functions in the cell, and helps protect cells from dying. HMGA1 is found at high levels in several types of cancer cells.;

NCIt note : HMGA1a is one of three protein products of the same gene, HMGA1, generated by alternative splicing. The HMGA1a protein contains three basic domains, named AT-hooks and an acidic C-terminal region. AT-hooks are responsible for binding to AT-rich sequences inside the minor groove of DNA. Phosphorylation of HMGA1a by both PKC and cdc-2 kinases strongly reduces its DNA binding affinity and is critical in cell cycle progression. HMGA1a activates the interferon-beta gene (IFN-beta) by functioning as the essential architectural component for the assembly and stability of the IFN-beta enhanceosome. (PMID11576996);

NCI Metathesaurus CUI : CL414496;

Codes from synonyms : CDR0000561598;

Details

Origin ID

C20322;

UMLS CUI

C5391635;

OMIM relation
- High mobility group at-hook 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HMGA1 protein, human [MeSH Supplementary Concept]
- HMGA1a protein [MeSH concept]
- hmga1a protein [MeSH Descriptor]
gene_encodes_gene_product
- HMGA1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- HMGA Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- AT Hook Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Progression [NCIt concept]
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Immune Response Process [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients