Preferred Label : HMG Family Gene;
NCIt definition : Human HMG Family Genes encode ubiquitous non-histone HMG chromatin proteins originally
named according to PAGE electrophoretic mobility, shared physical properties, and
association with chromatin. Canonical HMG proteins are subdivided into 3 superfamilies
with characteristic functional sequence motifs: HMGB (formerly HMG-1/-2), HMGN (formerly
HMG-14/-17), and HMGA (formerly HMG-I/Y/C). DNA-binding HMG proteins appear to have
roles in matrix stabilization, ssDNA protection, replication, and transcription that
influence cell growth, proliferation, differentiation, and death. (NCI);
Origin ID : C20570;
UMLS CUI : C1333918;
Semantic type(s)
- gene_encodes_gene_product
- gene_found_in_organism
- gene_plays_role_in_process
