HMGN Family Protein

Preferred Label : HMGN Family Protein;

NCIt synonyms : NBD Protein; HMG-14/-17; High Mobility Group N Protein;

NCIt definition : The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes, changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. They typically contain an NBD (Nucleosome Binding Domain) motif, which anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in higher order chromatin structure. The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin. (Trends Biochem Sci 2001 Jul;26(7):431-7);

Details

Origin ID

C20327;

UMLS CUI

C0949596;

Automatic exact mappings (from CISMeF team)
- HMGN proteins [MeSH concept]
- hmgn proteins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HMGN proteins [MeSH concept]
- hmgn proteins [MeSH Descriptor]
gene_encodes_gene_product
- HMG Family Gene [NCIt concept]
- HMGN Family Gene [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- DNA Topology Regulation [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_chemical_classification_of_gene_product
- High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 [NCIt concept]
- High Mobility Group Nucleosome-Binding Domain-Containing Protein 4 [NCIt concept]
- Non-Histone Chromosomal Protein HMG-14 [NCIt concept]
- Non-Histone Chromosomal Protein HMG-17 [NCIt concept]

Keyword's position in hierarchy(ies) :

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