NCIt synonyms : High Mobility Group N Gene Family;
NCIt definition : Human HMGN Family Genes encode nuclear HMGN proteins that bind to nucleosomes, change
chromatin architecture, and enhance transcription or replication. They typically contain
a Nucleosome Binding Domain that anchors these proteins to nucleosome cores to facilitate
changes in higher order chromatin structure. HMGN chromatin association is dynamic
and regulated by posttranslational modification; related to cell cycle and transcriptional
events. (NCI);
Semantic type(s)